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Research Molecules

Research Molecules

PNB Vesper is focused on developing cost-effective drugs for unmet medical needs. We have synthesized hundreds of molecules and systematically characterized them to select the lead molecules. The lead molecules have the potential to treat a variety of diseases including Covid 19, Inflammatory pain, Different kinds of Cancer, Inflammatory bowel disease (IBD), Neurological diseases such as Anxiety and Depression, Metabolic disorders, and others.

Molecules Molecular target Therapeutic indication Stage of development
PNB-001/ GPP-BALACOVIN

CCK2
CCK-B
CCK-B Gastrin

COVID 19
Inflammatory pain
IBD
Dysmenorrhea

Clinical Phase III
Clinical Phase II
SAD completed
MAD completed

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PNB-028

CCKc

Pancreatic cancer

Colon cancer

Preclinical development completed
Phase 1 / phase 2 trial approved for colon- and pancreatic cancer

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PNB-081

CCK1
CCK-A

Opiate potentiation/Opiate tolerance Pancreatitis

PK completed, preclinical
Development at toxicology

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PNB-102

CCK2
CCK-B

Gastric cancer
Lung cancer, small cell lung cancer only

Preclinical development
PK completed, proof of concept

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PNB-291

Pan-CCK
CCK1, CCK2

Brain cancer
Lung / liver cancer

Preclinical development Discovery

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