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PNB -091 for the Treatment of Cocaine addiction Disorder

PNB -091 is a mixed CCK antagonist. It blocks both CCK A & CCK B. For the alilino benzodiazepines and for the ureas, the best anxiolytic effect was always found for a mixed CCK antagonist. All the pre-clinical studies are completed. We have recently signed an agreement with the US government/ NIH to screen and develop PNB -091 further for cocaine Addiction.

Synthesis of Substituted 3-Anilino-5-phenyl-1,3-dihydro2H-1,4-benzodiazepine-2-ones and their Evaluation as


Anti-depressant and anti-nociceptive effects of 1,4-benzodiazepine-2-ones based cholecystokinin (CCK2) antagonists